This is such a strong card for Ghost-Spider. It is (to my knowledge) the first protection card that triggers her effect in the the player phase (if you have a Web-Warrior Ally that would take consequential damage and there are quite some of them that take two damage for one of their stats) but it can also be used in multiplayer to block multiple attacks and still be ready next turn (only downside is that one of your allies might be exhausted).

Here is how it work:

1. you defend the first attack normally
2. when one of the other players is attacked you block with one of your Web Warrior allies and then play Stronger Together to reduce the damage (hopefully to 0) and ready Ghost-Spider afterwards.
3. if really needed you could block another attack now since you are ready again.

This card's best use is to prevent consequential damage to allies. There are allies like Dum-Dum Dugan whose activations deal 2 damage to them, which gives you even more value. It also keeps allies like Ms Marvel and Mantis who damage themselves with their abilities around for longer. Very versatile card.

The reason why the damage is good is because you want to have damage to tuck cards under Ionic Physiology. But a Ressource card that can make up to 4 resources is also never bad. You could play an Avengers Mansion turn 1 with just this card alone and if you have any events with printed energy ressources you can then immediately tuck them under Ionic Physiology

The fact that you need to have damage to tuck cards here really makes this card and Wonder Man a tad bit worse. It means you usually can't tuck cards here on turn 1 and want to get damage somehow. Options to do it turn 1 are Clarity of Purpose, Toe to Toe, Taunt or Deathcry

A couple of more allies to consider pairing with this card:

 Colossus from Magik's kit: He can defend from hand with tough without exhausting

 Amadeus Cho from Herc's kit: 2 cost ally that can exhaust (no damage) to draw cards. Yes, you have to protect him from 
 minions, but if you get him early, that could be a TON of card draw