General Strategy

Attack:

Pressure the villain with a constant stream of damage coming in from Flurry of Blades, Psimitar and Psylocke's basic attacks.

Thwart:

Switch to double psi knife and play Mental Detection, and your basic thwart. Professor X can also help with thwarting and ready you for a potential 9 thwart this turn (3 from Professor, 3x2 from your basic thwart). If you play an identity card that can confuse the villain, it's always worth it to do so.

Defending:

Multiple Man is an excellent card that provides 3 thwart and 3 blocks for only 4 mana. The downside is that you HAVE to play him once you get him in your hand, otherwise you lose the value of getting all 3 on the board. It can happen that you draw 2 of them in your hand, but with a 4 card hand size it is less common. It's also important to have all 3 in your discard pile before your deck runs out and gets reshuffled.

Do not be afraid to use your basic defense either. You can play What Doesn't Kill Me using one of your katanas for the , to heal up and ready.

Priority setup:

Avengers Mansion , Psimitar and Helicarrier in that order. The rest of supports and upgrades are good to have but of less priority.

Flexible card spots:

Ready to Rumble is nice because you aim to flip to alter ego a lot. It allows you to recover and flip ready in your hero side. Assess the Situation allows you to increase your hand size for next turn. It is useful if there is 1 card remaining in your hand after playing everything.