Lethal Protector

Symbiote Suit can be used alongside or instead of Defensive Conditioning. Defensive Conditioning is primarily there instead of Symbiote Suit for the cheaper cost and to bring Venom's hp to a nice 15.

As this deck has a low amount of strength recourses, Enhanced Physique is used here to help pay for the cost of Grasping Tendrils alongside Venom's ability to get off that nice stun.

While Spider-Byte is not a Guardian, with the amount of tech upgrades Venom has in his identity kit this effectively turns Spider-Byte into a 0 cost card.

With the amount of defence events and upgrades you will not really be looking to flip to alter-ego often. This build should allow for a prolonged time out in hero mode to defend, take no damage and have a good draw to allow for a good damage output during the hero phase due to the amount of ready ups.