Contents: Doctor Octopus, Electro, Hobgoblin, Kraven the Hunter, Scorpion, and Vulture. The Sinister Six, Guerrila tactics, and standard encounter sets.

Setup: Choose X villains at random, where X is 1 more than the number of players. Put those villains into play, place the active counter on the villain with the lowest activation order value, and set the other villains aside. Put the Light at the End side scheme into play, trap! side faceup.