Pulling out the BIG guns...

Giant Man and Goliath are two big damage dealers and you can keep them going for a bit. Get Quinjets out every time you can. Don't be afraid to ditch one of your large allies if you can't afford them until later. Can get them back with Make the Call, which can be recycled with Leadership Training.

Rapid Response can make Goliath or Giant Man be a pain for the Villain. Once you get out your supports and upgrades, Giant Man has +7 ATK +5 THW and Goliath has +8 ATK +5 THW (Inspiring Presence and Earth's Mightiest Heroes works well when they are buffed). After they are all tapped out, a Teamwork can buff Wasp's basic attack in Giant Form can be +9 or +10 ATK when using a fully buffed Goliath or Giant Man, and can be spread among enemies.

U.S. Agent and War Machine are good blockers, War Machine is great against Retailiate.

Med Lab keeps the large allies ready for redeployment when you have the resources to play them again.